Highlanders will march into the cauldron of Mandava Stadium where they face former league champions FC Platinum on Saturday.
Bosso are coming from their Independence Cup 1-0 victory over their old time rivals Dynamos.
Bruised DeMbare, who are set to take on unpredictable Manica Diamonds, sit on the apex of the log with 23 points courtesy of a superior goal difference.
The Glamour Boys are at par with Joey Antipas’ Chicken Inn who are smarting from a shock 3-0 defeat at the hands of basement side Whawha.
Antipas described the defeat by Whawha as embarrassing and his charges will be looking to bounce back to winning ways quickly when they encounter City.
Gamecocks will battle against Philani “Beefy” Ncube’s Bulawayo City at Luveve Stadium.
National Sports Stadium will be the venue between Harare City and Black Rhinos. Tenax will fight it out against inconsistent Yadah FC at Sakubva Stadium.
ZPC Kariba have a date against Benjani Mwaruwari’s Ngezi Platinum Stars. In their last league encounter, Ngezi, drew nil all against DeMbare, which happened to be Mwaruwari’s second draw of the season.
On Sunday, sporadic and free-spending Bulawayo Chiefs will seek to utilise home advantage when they face Whawha at Emagumeni.
Triangle United will play host to former Cup Kings CAPS United while Craneborne Bullets take aim at Herentals at Mutare’s Sakubva Stadium.
Saturday: Tenax CS FC vs Yadah (Sakubva),
Harare City vs Black Rhinos (National Sports Stadium), FC Platinum vs Highlanders (Mandava), Chicken Inn vs Bulawayo City (Luveve), ZPC Kariba vs Ngezi Platinum Stars (Nyamhunga)
Sunday: Cranborne Bullets vs Herentals (Sakubva)